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Scientific and industry publications

An overview of the most important scientific papers and industry articles related to the Issuer's activities, as well as recommended external studies.

 

Our academic publications

 

¹Aleksiewicz, R., Iwanicki, R., Kostro, K., Kostrzewski, M., Sanford, J. and Sokołowski, A. (2013) Zastosowanie komórek macierzystych izolowanych z tkanki tłuszczowej w weterynaryjnej medycynie regeneracyjnej. Weterynaria w Praktyce, 1–2.

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²Klimczak, A., Kozłowska, U., Sanford, J., Walczak, P., Małysz-Cymborska, I. and Kurpisz, M. (2019) Immunological characteristics and properties of glial restricted progenitors of mice, canine primary culture suspensions, and human QSV40 immortalized cell lines for prospective therapies of neurodegenerative disorders. Cell Transplantation, 28(9–10), pp.1140–1154.
PubMed: https://pubmed.ncbi.nlm.nih.gov/31124369/
https://doi.org/10.1177/0963689719848355 .

Downoad PDF: https://pmc.ncbi.nlm.nih.gov/articles/PMC6767900/pdf/10.1177_0963689719848355.pdf 

³Malysz-Cymborska, I., Golubczyk, D., Kalkowski, L., Burczyk, A., Janowski, M., Holak, P., Olbrych, K., Sanford, J., Stachowiak, K., Milewska, K., Gorecki, P., Adamiak, Z., Maksymowicz, W. and Walczak, P. (2018) MRI-guided intrathecal transplantation of hydrogel-embedded glial progenitors in large animals. Scientific Reports, 8(1), p.16490.
PubMed: https://pubmed.ncbi.nlm.nih.gov/30405160/
https://doi.org/10.1038/s41598-018-34723-x.

Download PDF: https://www.nature.com/articles/s41598-018-34723-x.pdf

⁴Malysz-Cymborska, I., Golubczyk, D., Kalkowski, L., Kwiatkowska, J., Zawadzki, M., Głodek, J., Holak, P., Sanford, J., Milewska, K., Adamiak, Z., Walczak, P. and Janowski, M. (2021) Intra-arterial transplantation of stem cells in large animals as a minimally-invasive strategy for the treatment of disseminated neurodegeneration. Scientific Reports, 11(1), p.6581.
PubMed: https://pubmed.ncbi.nlm.nih.gov/33753789/
https://doi.org/10.1038/s41598-021-85820-3 .

Download PDF: https://www.nature.com/articles/s41598-021-85820-3.pdf

⁵Moll, M., Pfeuffer, J., Klenk, H.D., Niewiesk, S. and Maisner, A. (2004) Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivo. Journal of General Virology, 85(4), pp.1019–1027.
PubMed: https://pubmed.ncbi.nlm.nih.gov/15039544/
https://doi.org/10.1099/vir.0.19663-0

⁶Ohgimoto, S., Ohgimoto, K., Niewiesk, S., Klagge, I.M., Pfeuffer, J., Johnston, I.C.D., Schneider-Schaulies, J., Weidmann, A., Ter Meulen, V. and Schneider-Schaulies, S. (2001) The haemagglutinin protein is an important determinant of measles virus tropism for dendritic cells in vitro. Journal of General Virology, 82(8), pp.1835–1844.
PubMed: https://pubmed.ncbi.nlm.nih.gov/11457989/
https://doi.org/10.1099/0022-1317-82-8-1835 .

⁷Pfeuffer, J., Püschel, K., Ter Meulen, V., Schneider-Schaulies, J. and Niewiesk, S. (2003) Extent of measles virus spread and immune suppression differentiates between wild-type and vaccine strains in the cotton rat model (Sigmodon hispidus). Journal of Virology, 77(1), pp.150–158.
PubMed: https://pubmed.ncbi.nlm.nih.gov/12477820/
doi:10.1128/jvi.77.1.150-158.2003.

Download PDF/EPUB: Extent of Measles Virus Spread and Immune Suppression Differentiates between Wild-Type and Vaccine Strains in the Cotton Rat Model (Sigmodon hispidus

⁸Rogujski, P., Gewartowska, M., Fiedorowicz, M., Frontczak-Baniewicz, M., Sanford, J., Walczak, P., Janowski, M., Lukomska, B. and Stanaszek, L. (2024) Multisite injections of canine glial-restricted progenitors promote brain myelination and extend the survival of dysmyelinated mice. International Journal of Molecular Sciences, 25(19), p.10580.
PubMed: https://pubmed.ncbi.nlm.nih.gov/39408910/
doi:10.3390/ijms251910580.

⁹Skwarcz, S., Bryzek, I., Gregosiewicz, A., Warda, E., Gawęda, K., Tarczyńska, M., Węgłowski, R., Skwarcz, J., Nadulski, R., Starek, A. and Sanford, J. (2019) Autologous activated platelet-rich plasma (PRP) in bone tissue healing – does it work? Assessment of PRP effect on bone defect healing in animal models. Polish Journal of Veterinary Sciences, 22(1), pp.109–115.
PubMed: https://pubmed.ncbi.nlm.nih.gov/30997778/
doi:10.24425/pjvs.2019.127077.

Download PDF: Autologous activated platelet-rich plasma (PRP) in bone tissue healing – does it work? Assessment of PRP effect on bone defect healing in animal models - Polish Journal of Veterinary Sciences - Czasopisma PAN

¹⁰Skwarcz, S., Bryzek, I., Gregosiewicz, A., Warda, E., Gawęda, K., Tarczyńska, M., Skwarcz, J., Nadulski, R., Starek, A. and Sanford, J. (2019) The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models. Polish Journal of Veterinary Sciences, 22(2), pp.243–250.
PubMed: https://pubmed.ncbi.nlm.nih.gov/31269346/
doi:10.24425/pjvs.2019.127092.

Download PDF: The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models - Polish Journal of Veterinary Sciences - Czasopisma PAN

¹¹Stanaszek, L., Majchrzak, M., Drela, K., Rogujski, P., Sanford, J., Fiedorowicz, M., Gewartowska, M., Frontczak-Baniewicz, M., Walczak, P., Lukomska, B. and Janowski, M. (2021) Myelin-independent therapeutic potential of canine glial-restricted progenitors transplanted in mouse model of dysmyelinating disease. Cells, 10(11), p.2968.
PubMed: https://pubmed.ncbi.nlm.nih.gov/34831191/
https://doi.org/10.3390/cells10112968

Recommended external studies

 

¹²Baouche, M., Ochota, M., Locatelli, Y. and Mermillod, P., 2023. Mesenchymal stem cells: generalities and clinical significance in feline and canine medicine. Animals, 13(12), p.1903. https://doi.org/10.3390/ani13121903

Download PDF: https://www.mdpi.com/2076-2615/13/12/1903/pdf?version=1686124190

 

               This review article summarises the current state of knowledge on the biology and applications of mesenchymal stem                cells (MSCs) in veterinary medicine for dogs and cats. The authors describe the sources of MSCs (bone marrow,                      adipose tissue, umbilical cord blood, foetal membranes), their immunomodulatory properties and therapeutic                            potential in tissue regeneration.

             The clinical section presents the results of studies on the effectiveness of MSCs in the treatment of osteoarthritis,                     tendon injuries, chronic renal failure, asthma and enteritis in cats. The article emphasises the safety of the therapy, t.                 the absence of side effects and the need for further standardisation of procedures in light of EMA and FDA guidelines.

             The publication is an important reference point for the development of Sanford Biotech's translational cell therapies.

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¹³Cho, H.-S., Song, W.-J., Nam, A., Li, Q., An, J.-H., Ahn, J.-O., Kim, H.-T., Park, S.-M., Ryu, M.-O., Kim, M.-C., Kim, J.-H., Youn, H.-Y. (2024). Intravenous injection of allogenic canine mesenchymal stem cells in 40 client-owned dogs: a safety assessment in veterinary clinical trials. BMC Veterinary Research, 20(1), 375. DOI: 10.1186/s12917-024-04216-3 Pobierz PDF: https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-024-04216-3.pdf

 

A retrospective study of 40 cases (314 cases in total in the database) of dogs that were administered intravenous allogeneic MSCs obtained from adipose tissue (AT-MSCs). Adverse effects were monitored for at least 6 months after administration. Clinical parameters, blood tests, radiological images and the presence of tumours were analysed. No significant clinical or haematological changes were observed in most animals. In three cases, a local reaction (pain, swelling, vasculitis) occurred, which resolved within a week. No cases of thrombosis, pulmonary oedema, bleeding or tumour development were observed during the observation period. The authors conclude that intravenous administration of allogeneic MSCs is a safe therapeutic approach in dogs.

¹⁴Morawska-Kozłowska M, Pitas M, Zhalniarovich Y. 2025. Mesenchymal Stem Cells in Veterinary Medicine—Still Untapped Potential. Animals. 2025; 15(8):1175.

https://doi.org/10.3390/ani15081175

Download PDF: https://www.mdpi.com/2076-2615/15/8/1175/pdf

 

The review article analyses the current status of MSC applications in veterinary medicine in various species (dogs, cats, horses, cattle), highlighting challenges in clinical trials, cell standardisation, safety, MSC population heterogeneity and regulatory aspects. The authors emphasise that despite progress, there are significant barriers to translation into widespread clinical use, such as the lack of clear administration protocols, differences between donors, potential immunological risks, and the need for long-term monitoring of adverse events.

¹⁵ Zhang X, Kuang Q, Xu J, Lin Q, Chi H, Yu D. 2024. MSC-Based Cell Therapy in Neurological Diseases: A Concise Review of the Literature in Pre-Clinical and Clinical Research. Biomolecules 14(5):538.

https://doi.org/10.3390/biom14050538

 

A review of the literature indicates that MSCs can be used in neurological diseases: stroke, multiple sclerosis, spinal cord injuries. The authors discuss the mechanisms of action (neuroprotection, angiogenesis, inflammation modulation) and current limitations: cell migration to the site of damage, cell survival, immune barrier.