Toxic nephropathy and proteinuria in cats – modern biological therapies

Introduction

Kidney disease is a common problem in cats, especially in older cats. Toxic nephropathy can be caused by poisoning with drugs, toxins or other substances that damage the kidneys. Proteinuria, or excessive protein excretion in the urine, is a symptom of glomerular filtration damage, often associated with chronic kidney disease (CKD). Both conditions lead to a deterioration in the animal's general condition and a shortened life span.

 

Symptoms of nephropathy and proteinuria:

 

  • increased thirst and more frequent urination,
  • weight loss, loss of appetite, apathy,
  • vomiting, dehydration, deterioration of coat condition,
  • oedema with severe protein loss,
  • changes in laboratory tests: elevated urea, creatinine, presence of protein in urine.

 

Standard treatment

To date, treatment has consisted of a renal diet, supplements to support kidney function, medicines to control blood pressure, and pharmacotherapy to reduce proteinuria (e.g. ACE inhibitors, ARBs). This treatment improves quality of life but does not halt the progression of the disease.

 

Modern biological therapies

 

Mesenchymal stem cells (MSCs)

MSCs support renal parenchymal regeneration through trophic and immunomodulatory effects. They reduce inflammation, improve glomerular filtration and may reduce proteinuria. Clinical studies in cats with chronic renal failure indicate an improvement in biochemical parameters after MSC administration.

 👉 Check out how mesenchymal stem cells work

 

 

Summary

Toxic nephropathy and proteinuria in cats are serious health problems that shorten life and reduce its quality. Standard treatment slows down the progression of the disease, but only MSC biological therapies offer the chance to improve kidney function and support regenerative processes.

 

FAQ

Can kidney disease in cats be cured?
Do MSCs work in toxic nephropathy?
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